| EC |
4.2.3.164 |
| Accepted name: |
(+)-eremophilene synthase |
| Reaction: |
(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate |
|
For diagram of eremophilane and spirovetivane sesquiterpenoid biosynthesis, click here |
| Glossary: |
(+)-eremophilene = (3S,4aS,5R)-4a,5-dimethyl-3-(prop-1-en-2-yl)-1,2,3,4,4a,5,6,7-octahydronaphthalene |
| Other name(s): |
STC3 (gene name); geoA (gene name) |
| Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-eremophilene-forming] |
| Comments: |
The enzyme has been identified in the myxobacterium Sorangium cellulosum and in the fungus Fusarium fujikuroi. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Schifrin, A., Ly, T.T., Gunnewich, N., Zapp, J., Thiel, V., Schulz, S., Hannemann, F., Khatri, Y. and Bernhardt, R. Characterization of the gene cluster CYP264B1-geoA from Sorangium cellulosum So ce56: biosynthesis of (+)-eremophilene and its hydroxylation. ChemBioChem 16 (2015) 337–344. [DOI] [PMID: 25504914] |
| 2. |
Burkhardt, I., Siemon, T., Henrot, M., Studt, L., Rosler, S., Tudzynski, B., Christmann, M. and Dickschat, J.S. Mechanistic characterisation of two sesquiterpene cyclases from the plant pathogenic fungus Fusarium fujikuroi. Angew. Chem. Int. Ed. Engl. 55 (2016) 8748–8751. [DOI] [PMID: 27294564] |
|
| [EC 4.2.3.164 created 2017] |
| |
|
| |
|
Printable version