| EC |
4.2.3.180 |
| Accepted name: |
pseudolaratriene synthase |
| Reaction: |
geranylgeranyl diphosphate = pseudolaratriene + diphosphate |
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For diagram of miscellaneous diterpenoid biosynthesis, click here |
| Glossary: |
pseudolaradiene = (1RS,3aSR,8aRS)-3a,6-dimethyl-1-(6-methylhepta-2,5-dien-2-yl)-1,2,3,3a,4,7,8,8a-octahydrohydroazulene |
| Other name(s): |
PxaTPS8 |
| Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, pseudolaradiene-forming) |
| Comments: |
Isolated from the plant Pseudolarix amabilis (golden larch). The product is oxidized to pseudolaric acid B, a microtubule-destabilizing agent. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Mafu, S., Karunanithi, P.S., Palazzo, T.A., Harrod, B.L., Rodriguez, S.M., Mollhoff, I.N., O'Brien, T.E., Tong, S., Fiehn, O., Tantillo, D.J., Bohlmann, J. and Zerbe, P. Biosynthesis of the microtubule-destabilizing diterpene pseudolaric acid B from golden larch involves an unusual diterpene synthase. Proc. Natl. Acad. Sci. USA 114 (2017) 974–979. [DOI] [PMID: 28096378] |
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| [EC 4.2.3.180 created 2017] |
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