ExplorEnz: EC 4.2.3.185

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4.2.3.185

Accepted name:

ent-atiserene synthase

Reaction:

ent-copalyl diphosphate = ent-atiserene + diphosphate

For diagram of biosynthesis of diterpenoids from ent-copalyl diphosphate, click here and for diagram of ent-atiserene, ent-kaurene and ent-isokaurene, click here

Other name(s):

IrKSL4; AcKSL1; ApKSL1; AtKSL1; AsKSL1

Systematic name:

ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-atiserine-forming)

Comments:

Isolated from the plant Isodon rubescens and several species of Aconitum as well as species of Streptomyces.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Smanski, M.J., Yu, Z., Casper, J., Lin, S., Peterson, R.M., Chen, Y., Wendt-Pienkowski, E., Rajski, S.R. and Shen, B. Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proc. Natl. Acad. Sci. USA 108 (2011) 13498–13503. [DOI] [PMID: 21825154]
2.	Jin, B., Cui, G., Guo, J., Tang, J., Duan, L., Lin, H., Shen, Y., Chen, T., Zhang, H. and Huang, L. Functional diversification of kaurene synthase-like genes in Isodon rubescens. Plant Physiol. 174 (2017) 943–955. [DOI] [PMID: 28381502]
3.	Tian, M., Jin, B., Chen, L., Ma, R., Ma, Q., Li, X., Chen, T., Guo, J., Ge, H., Zhao, X., Lai, C., Tang, J., Cui, G. and Huang, L. Functional diversity of diterpene synthases in Aconitum plants. Plant Physiol. Biochem. 202:107968 (2023). [DOI] [PMID: 37619270]

[EC 4.2.3.185 created 2017]