| EC |
4.2.3.187 |
| Accepted name: |
(2Z,6E)-hedycaryol synthase |
| Reaction: |
(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate |
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For diagram of biosynthesis of ent-germacrene sesquiterpenoids, click here |
| Glossary: |
(2Z,6E)-hedycaryol = (1E,4Z,7S)-germacra-1(10),4-dien-11-ol |
| Other name(s): |
HcS |
| Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (2Z,6E)-hedycaryol-forming] |
| Comments: |
Isolated from the bacterium Kitasatospora setae. The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization. See also EC 4.2.3.174 (2E,6E)-hedycaryol synthase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Baer, P., Rabe, P., Citron, C.A., de Oliveira Mann, C.C., Kaufmann, N., Groll, M. and Dickschat, J.S. Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism. ChemBioChem 15 (2014) 213–216. [DOI] [PMID: 24399794] |
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| [EC 4.2.3.187 created 2017] |
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