ExplorEnz: EC 4.2.3.188

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4.2.3.188

Accepted name:

β-geranylfarnesene synthase

Reaction:

(1) all-trans-geranylfarnesyl diphosphate = β-geranylfarnesene + diphosphate
(2) all-trans-hexaprenyl diphosphate = β-hexaprene + diphosphate
(3) all-trans-heptaprenyl diphosphate = β-heptaprene + diphosphate

For diagram of sesquarterpenoid biosynthesis, click here and for diagram of sesterterpenoids biosynthesis, click here

Glossary:

β-geranylfarnesene = (6E,10E,14E)-7,11,15,19-tetramethyl-3-methyleneicosa-1,6,10,14,18-pentaene

Other name(s):

Bcl-TS

Systematic name:

all-trans-geranylfarnesyl-diphosphate diphosphate-lyase (β-geranylfarnesene-forming)

Comments:

Isolated from the bacterium Bacillus clausii. The enzyme acts on a range of polyprenyl diphosphates.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Sato, T., Yamaga, H., Kashima, S., Murata, Y., Shinada, T., Nakano, C. and Hoshino, T. Identification of novel sesterterpene/triterpene synthase from Bacillus clausii. ChemBioChem 14 (2013) 822–825. [DOI] [PMID: 23554321]
2.	Ueda, D., Yamaga, H., Murakami, M., Totsuka, Y., Shinada, T. and Sato, T. Biosynthesis of sesterterpenes, head-to-tail triterpenes, and sesquarterpenes in Bacillus clausii: identification of multifunctional enzymes and analysis of isoprenoid metabolites. ChemBioChem 16 (2015) 1371–1377. [DOI] [PMID: 25882275]

[EC 4.2.3.188 created 2017]