EC |
4.2.3.191 |
Accepted name: |
cycloaraneosene synthase |
Reaction: |
geranylgeranyl diphosphate = cycloaraneosene + diphosphate |
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For diagram of biosynthesis of fusicoccane diterpenoids, click here |
Glossary: |
cycloaraneosene = (1R,3aR,9aS,10aR)-1,9a-dimethyl-4-methylene-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a,10,10a-dodecahydrodicyclopenta[a,d][8]annulene |
Other name(s): |
SdnA |
Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase (cycloaraneosene-forming) |
Comments: |
Isolated from the fungus Sordaria araneosa. Cycloaraneosene is a precursor of the antibiotic sordarin. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Kudo, F., Matsuura, Y., Hayashi, T., Fukushima, M. and Eguchi, T. Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase. J. Antibiot. (Tokyo) 69 (2016) 541–548. [DOI] [PMID: 27072286] |
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[EC 4.2.3.191 created 2017] |
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