| EC |
4.2.3.203 |
| Accepted name: |
isoelisabethatriene synthase |
| Reaction: |
geranylgeranyl diphosphate = isoelisabethatriene + diphosphate |
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For mechanism, click here and for diagram of miscellaneous diterpenoid biosynthesis, click here |
| Glossary: |
isoelisabethatriene = (1S,4R)-4,7-dimethyl-1-[(2R)-6-methylhept-5-en-2-yl]-1,2,3,4,5,6-hexahydronaphthalene |
| Other name(s): |
HpS (ambiguous) |
| Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, isoelisabethatriene-forming) |
| Comments: |
Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is involved in a 1,3-hydride shift to the side-chain. The enzyme also produces hydropyrene, hydropyrenol, and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.202, hydropyrenol synthase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Rinkel, J., Rabe, P., Chen, X., Kollner, T.G., Chen, F. and Dickschat, J.S. Mechanisms of the diterpene cyclases β-pinacene synthase from Dictyostelium discoideum and hydropyrene synthase from Streptomyces clavuligerus. Chem. Eur. J. 23 (2017) 10501–10505. [PMID: 28696553] |
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| [EC 4.2.3.203 created 2019] |
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