| EC |
4.2.3.206 |
| Accepted name: |
(–)-cyatha-3,12-diene synthase |
| Reaction: |
geranylgeranyl diphosphate = (–)-cyatha-3,12-diene + diphosphate |
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For diagram of related fungal and bacterial diterpenoids, click here |
| Glossary: |
(–)-cyatha-3,12-diene = (3aS,5aS,10aS)-3a,5a,8-trimethyl-1-(propan-2-yl)-2,3,4,5,6,9,10,10a-octahydrocyclohepta[e]indene |
| Other name(s): |
eriG (gene name); CyaTC |
| Systematic name: |
geranylgeranyl diphosphate-lyase [(–)-cyatha-3,12-diene-forming] |
| Comments: |
The enzyme, characterized from the fungi Hericium erinaceus and Cyathus africanus, requires Mg2+ for activity. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Yang, Y.L., Zhang, S., Ma, K., Xu, Y., Tao, Q., Chen, Y., Chen, J., Guo, S., Ren, J., Wang, W., Tao, Y., Yin, W.B. and Liu, H. Discovery and characterization of a new family of diterpene cyclases in bacteria and fungi. Angew. Chem. Int. Ed. Engl. 56 (2017) 4749–4752. [DOI] [PMID: 28371074] |
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| [EC 4.2.3.206 created 2022] |
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