| EC |
4.2.3.214 |
| Accepted name: |
dolasta-1(15),8-diene synthase |
| Reaction: |
geranylgeranyl diphosphate = (5R,12R,14S)-dolasta-1(15),8-diene + diphosphate |
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For diagram of dolastadiene and δ-araneosene biosynthesis, click here |
| Glossary: |
(5R,12R,14S)-dolasta-1(15),8-diene = (3aR,4aS,8aR)-3a,8a-dimethyl-5-methylene-1-(propan-2-yl)-2,3,3a,4,4a,5,6,7,8,8a,9,10-dodecahydrobenzo[f]azulene |
| Other name(s): |
Cg113742 (gene name); CgDS |
| Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, dolasta-1(15),8-diene-forming] |
| Comments: |
Isolated from Colletotrichum gloeosporioides, a pathogenic fungus that causes bitter rot in variety of crops. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Bian, G., Rinkel, J., Wang, Z., Lauterbach, L., Hou, A., Yuan, Y., Deng, Z., Liu, T. and Dickschat, J.S. A clade II-D fungal chimeric diterpene synthase from Colletotrichum gloeosporioides produces dolasta-1(15),8-diene. Angew. Chem. Int. Ed. Engl. 57 (2018) 15887–15890. [DOI] [PMID: 30277637] |
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| [EC 4.2.3.214 created 2023] |
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