The Enzyme Database

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EC 4.2.3.214     
Accepted name: dolasta-1(15),8-diene synthase
Reaction: geranylgeranyl diphosphate = (5R,12R,14S)-dolasta-1(15),8-diene + diphosphate
For diagram of dolastadiene and δ-araneosene biosynthesis, click here
Glossary: (5R,12R,14S)-dolasta-1(15),8-diene = (3aR,4aS,8aR)-3a,8a-dimethyl-5-methylene-1-(propan-2-yl)-2,3,3a,4,4a,5,6,7,8,8a,9,10-dodecahydrobenzo[f]azulene
Other name(s): Cg113742 (gene name); CgDS
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, dolasta-1(15),8-diene-forming]
Comments: Isolated from Colletotrichum gloeosporioides, a pathogenic fungus that causes bitter rot in variety of crops.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Bian, G., Rinkel, J., Wang, Z., Lauterbach, L., Hou, A., Yuan, Y., Deng, Z., Liu, T. and Dickschat, J.S. A clade II-D fungal chimeric diterpene synthase from Colletotrichum gloeosporioides produces dolasta-1(15),8-diene. Angew. Chem. Int. Ed. Engl. 57 (2018) 15887–15890. [DOI] [PMID: 30277637]
[EC 4.2.3.214 created 2023]
 
 


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