ExplorEnz: EC 4.2.3.221

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4.2.3.221

Accepted name:

macrophomene synthase

Reaction:

all-trans-hexaprenyl diphosphate = macrophomene + diphosphate

For diagram of non-squalene triterpenoid biosynthesis, click here

Glossary:

macrophomene = (1S,22R)-tricyclo[20.1.0^1,22]docosa-2,6,10,14,18-pentaene

Other name(s):

MpMS

Systematic name:

pentaprenyl-diphosphate diphosphate-lyase [cyclizing, macrophomene-forming]

Comments:

Isolated from Macrophomina phaseolina, a pathogenic fungus that causes damping off, seedling blight, collar rot, stem rot, charcoal rot, basal stem rot, and root rot on many plant species. The 22-membered ring in macrophomene represents the largest macrocycle discovered in terpenes so far.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Tao, H., Lauterbach, L., Bian, G., Chen, R., Hou, A., Mori, T., Cheng, S., Hu, B., Lu, L., Mu, X., Li, M., Adachi, N., Kawasaki, M., Moriya, T., Senda, T., Wang, X., Deng, Z., Abe, I., Dickschat, J.S. and Liu, T. Discovery of non-squalene triterpenes. Nature 606 (2022) 414–419. [DOI] [PMID: 35650436]

[EC 4.2.3.221 created 2024]