| EC |
4.2.3.226 |
| Accepted name: |
(+)-2-epi-prezizaene synthase |
| Reaction: |
(2Z,6E)-farnesyl diphosphate = (+)-2-epi-prezizaene + diphosphate |
| Other name(s): |
EAS3 (gene name); EAS4 (gene name) |
| Systematic name: |
(2Z,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-2-epi-prezizaene-forming) |
| Comments: |
The enzyme occurs in plants. The initial cyclization product is a (7R)-β-bisabolyl cation. The major final product is (+)-2-epi-prezizaene. Other products are (–)-α-cedrene (cf. EC 4.2.3.227, (–)-α-cedrene synthase), small amounts of (–)-β-curcumene, and other sesquiterpenes with less than 10% yield. The enzyme also catalyses the reaction of EC 4.2.3.61, 5-epiaristolochene synthase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Noel, J.P., Dellas, N., Faraldos, J.A., Zhao, M., Hess, B.A., Jr., Smentek, L., Coates, R.M. and O'Maille, P.E. Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. ACS Chem. Biol. 5 (2010) 377–392. [DOI] [PMID: 20175559] |
| 2. |
Faraldos, J.A., O'Maille, P.E., Dellas, N., Noel, J.P. and Coates, R.M. Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate. J. Am. Chem. Soc. 132 (2010) 4281–4289. [DOI] [PMID: 20201526] |
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| [EC 4.2.3.226 created 2024] |
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