| EC |
4.2.3.37 |
| Accepted name: |
epi-isozizaene synthase |
| Reaction: |
(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate |
|
For diagram of biosynthesis of tricyclic sesquiterpenoids derived from bisabolyl cation, click here and for diagram of bisabolene derived sesquiterpenoid biosynthesis, click here |
| Other name(s): |
SCO5222 protein |
| Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] |
| Comments: |
Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.15.39, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Lin, X., Hopson, R. and Cane, D.E. Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. J. Am. Chem. Soc. 128 (2006) 6022–6023. [DOI] [PMID: 16669656] |
| 2. |
Zhao, B., Lin, X., Lei, L., Lamb, D.C., Kelly, S.L., Waterman, M.R. and Cane, D.E. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). J. Biol. Chem. 283 (2008) 8183–8189. [DOI] [PMID: 18234666] |
|
| [EC 4.2.3.37 created 2008] |
| |
|
| |
|
Printable version