ExplorEnz: EC 4.2.3.90

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4.2.3.90

Accepted name:

5-epi-α-selinene synthase

Reaction:

(2E,6E)-farnesyl diphosphate = 5-epi-α-selinene + diphosphate

For diagram of eudesmol and selinene biosynthesis, click here

Glossary:

5-epi-α-selinene = 5β-eudesma-3,11-diene = (2R,4aR,8aS)-1,2,3,4,4a,5,6,8a-octahydro-4a,8-dimethyl-2-(prop-1-en-2-yl)naphthalene
[= 8a-epi-α-selinene which uses naththalene numbering not eudesmane]

Other name(s):

8a-epi-α-selinene synthase; NP1

Systematic name:

(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 5-epi-α-selinene-forming)

Comments:

Requires Mg²⁺. The enzyme forms 5-epi-α-selinene possibly via germecrene A or a 1,6-hydride shift mechanism.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Agger, S.A., Lopez-Gallego, F., Hoye, T.R. and Schmidt-Dannert, C. Identification of sesquiterpene synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. strain PCC 7120. J. Bacteriol. 190 (2008) 6084–6096. [DOI] [PMID: 18658271]

[EC 4.2.3.90 created 2011]