| EC |
4.2.3.93 |
| Accepted name: |
δ-guaiene synthase |
| Reaction: |
(2E,6E)-farnesyl diphosphate = δ-guaiene + diphosphate |
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For diagram of guaiene, α-gurjunene, patchoulol and viridiflorene biosynthesis, click here |
| Glossary: |
δ-guaiene = α-bulnesene |
| Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, δ-guaiene-forming) |
| Comments: |
Requires Mg2+. In Aquilaria crassna three clones of the enzyme gave about 80% δ-guaiene and 20% α-guaiene (see also EC 4.2.3.87). A fourth clone gave 54% δ-guaiene and 45% α-guaiene [2].
The enzyme from Pogostemon cablin gives 13% δ-guaiene as well as 37% (-)-patchoulol (see EC 4.2.3.70), 13% α-guaiene (see EC 4.2.3.87), and traces of at least ten other sesquiterpenoids [1]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Deguerry, F., Pastore, L., Wu, S., Clark, A., Chappell, J. and Schalk, M. The diverse sesquiterpene profile of patchouli, Pogostemon cablin, is correlated with a limited number of sesquiterpene synthases. Arch. Biochem. Biophys. 454 (2006) 123–136. [DOI] [PMID: 16970904] |
| 2. |
Kumeta, Y. and Ito, M. Characterization of δ-guaiene synthases from cultured cells of Aquilaria, responsible for the formation of the sesquiterpenes in agarwood. Plant Physiol. 154 (2010) 1998–2007. [DOI] [PMID: 20959422] |
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| [EC 4.2.3.93 created 2011] |
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