ExplorEnz: EC 4.2.3.99

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4.2.3.99

Accepted name:

labdatriene synthase

Reaction:

9α-copalyl diphosphate = (12E)-9α-labda-8(17),12,14-triene + diphosphate

For diagram of diterpenoids from 9α-copalyl diphosphate, click here

Glossary:

9α-copalyl diphosphate = syn-copalyl diphosphate = (2E)-3-methyl-5-[(1R,4aS,8aS)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]pent-2-en-1-yl trihydrogen diphosphate
(12E)-9α-labda-8(17),12,14-triene = (4aS,5R,8aS)-1,1,4a-trimethyl-6-methylidene-5-[(2E)-3-methylpenta-2,4-dien-1-yl]decahydronaphthalene

Other name(s):

OsKSL10 (gene name)

Systematic name:

9α-copalyl-diphosphate diphosphate-lyase [(12E)-9α-labda-8(17),12,14-triene-forming]

Comments:

The enzyme from rice (Oryza sativa), expressed in Escherichia coli, also produces ent-sandaracopimara-8(14),15-diene from ent-copalyl diphosphate, another naturally occuring copalyl isomer in rice (cf. ent-sandaracopimaradiene synthase, EC 4.2.3.29).

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

Morrone, D., Hillwig, M.L., Mead, M.E., Lowry, L., Fulton, D.B. and Peters, R.J. Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals. Biochem. J. 435 (2011) 589–595. [DOI] [PMID: 21323642]

[EC 4.2.3.99 created 2012]