EC |
4.3.2.8 |
Accepted name: |
γ-glutamylamine cyclotransferase |
Reaction: |
ε-(γ-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline |
Other name(s): |
GGACT |
Systematic name: |
ε-(γ-L-glutamyl)-L-lysine γ-glutamyl cyclotransferase (5-oxo-L-proline producing) |
Comments: |
The enzyme, found in vertebrates, has no activity toward α-(γ-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9, γ-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the γ-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
References: |
1. |
Fink, M.L., Chung, S.I. and Folk, J.E. γ-Glutamylamine cyclotransferase: specificity toward ε-(L-γ-glutamyl)-L-lysine and related compounds. Proc. Natl. Acad. Sci. USA 77 (1980) 4564–4568. [DOI] [PMID: 6107907] |
2. |
Oakley, A.J., Coggan, M. and Board, P.G. Identification and characterization of γ-glutamylamine cyclotransferase, an enzyme responsible for γ-glutamyl-ε-lysine catabolism. J. Biol. Chem. 285 (2010) 9642–9648. [DOI] [PMID: 20110353] |
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[EC 4.3.2.8 created 2017] |
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