| EC |
4.4.1.21 |
| Accepted name: |
S-ribosylhomocysteine lyase |
| Reaction: |
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione |
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For diagram of autoinducer AI-2 biosynthesis, click here |
| Other name(s): |
S-ribosylhomocysteinase; LuxS |
| Systematic name: |
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming] |
| Comments: |
Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density [2]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37288-63-4 |
| References: |
| 1. |
Zhu, J., Dizin, E., Hu, X., Wavbreille, A.S., Park, J. and Pei, D. S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein. Biochemistry 42 (2003) 4717–4726. [DOI] [PMID: 12705835] |
| 2. |
Miller, M.B. and Bassler, B.L. Quorum sensing in bacteria. Annu. Rev. Microbiol. 55 (2001) 165–199. [DOI] [PMID: 11544353] |
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| [EC 4.4.1.21 created 2004] |
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