The Enzyme Database

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Accepted name: C-phycoerythrin α-cysteine-82 phycoerythrobilin lyase
Reaction: a [C-phycoerythrin α-subunit]-Cys82-phycoerythrobilin = apo-[C-phycoerythrin α-subunit] + (3E)-phycoerythrobilin
Other name(s): cpeY (gene name)
Systematic name: [C-phycoerythrin α-subunit]-Cys82-phycoerythrobilin:phycoerythrobilin lyase
Comments: The enzyme, characterized from the cyanobacterium Microchaete diplosiphon, catalyses the attachment of the phycobilin chromophore (3E)-phycoerythrobilin (PEB) to cysteine 82 of the α subunit of the phycobiliprotein C-phycoerythrin. The numbering used here corresponds to the enzyme from Microchaete diplosiphon, and could vary slightly in other organisms. Activity is greatly enhanced in the presence of the chaperone-like protein CpeZ. The reaction could also be catalysed by EC, phycobiliprotein cysteine-84 phycobilin lyase, but much less efficiently.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Biswas, A., Boutaghou, M.N., Alvey, R.M., Kronfel, C.M., Cole, R.B., Bryant, D.A. and Schluchter, W.M. Characterization of the activities of the CpeY, CpeZ, and CpeS bilin lyases in phycoerythrin biosynthesis in Fremyella diplosiphon strain UTEX 481. J. Biol. Chem. 286 (2011) 35509–35521. [DOI] [PMID: 21865169]
2.  Kronfel, C.M., Biswas, A., Frick, J.P., Gutu, A., Blensdorf, T., Karty, J.A., Kehoe, D.M. and Schluchter, W.M. The roles of the chaperone-like protein CpeZ and the phycoerythrobilin lyase CpeY in phycoerythrin biogenesis. Biochim Biophys Acta Bioenerg 1860:S0005-2728( (2019). [DOI] [PMID: 31173730]
[EC created 2021]

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