The Enzyme Database

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Accepted name: (2S)-3-sulfopropanediol sulfolyase
Reaction: (2S)-2,3-dihydroxypropane-1-sulfonate = hydroxyacetone + sulfite
Glossary: (2S)-2,3-dihydroxypropane-1-sulfonate = (2S)-3-sulfopropanediol
Other name(s): DHPS sulfolyase; hpsG (gene name)
Systematic name: (2S)-2,3-dihydroxypropane-1-sulfonate sulfite-lyase
Comments: The enzyme, characterized from the human gut bacterium Bilophila wadsworthia, contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (AdoMet) and a [4Fe-4S] cluster.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Liu, J., Wei, Y., Lin, L., Teng, L., Yin, J., Lu, Q., Chen, J., Zheng, Y., Li, Y., Xu, R., Zhai, W., Liu, Y., Liu, Y., Cao, P., Ang, E.L., Zhao, H., Yuchi, Z. and Zhang, Y. Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate. Proc. Natl. Acad. Sci. USA 117 (2020) 15599–15608. [DOI] [PMID: 32571930]
[EC created 2021]

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