The Enzyme Database

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Accepted name: canavanine-γ-lyase
Reaction: L-canavanine + H2O = L-homoserine + N-hydroxyguanidine (overall reaction)
(1a) L-canavanine = vinylglycine + N-hydroxyguanidine
(1b) vinylglycine = (2E)-2-aminobut-2-enoate (spontaneous)
(1c) (2E)-2-aminobut-2-enoate + H2O = L-homoserine (spontaneous)
Other name(s): CangL
Systematic name: L-canavanine N-hydroxyguanidine-lyase (L-homoserine-forming)
Comments: A pyridoxal 5′-phosphate protein. The enzyme, characterized from the bacterium Pseudomonas canavaninivorans, cleaves a carbon-oxygen bond, releasing N-hydroxyguanidine and an unstable enamine product that tautomerizes to an imine form, which is attacked by a water molecule to form L-homoserine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Hauth, F., Buck, H., Stanoppi, M. and Hartig, J.S. Canavanine utilization via homoserine and hydroxyguanidine by a PLP-dependent γ-lyase in Pseudomonadaceae and Rhizobiales. RSC Chem. Biol. 3 (2022) 1240–1250. [DOI] [PMID: 36320885]
[EC created 2022]

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