The Enzyme Database

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Accepted name: lactoylglutathione lyase
Reaction: (R)-S-lactoylglutathione = glutathione + 2-oxopropanal
Glossary: 2-oxopropanal = methylglyoxal
Other name(s): methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing)
Systematic name: (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
Comments: Also acts on 3-phosphoglycerol-glutathione.
Links to other databases: BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9033-12-9
1.  Ekwall, K. and Mannervik, B. The stereochemical configuration of the lactoyl group of S-lactoylglutathionine formed by the action of glyoxalase I from porcine erythrocytes and yeast. Biochim. Biophys. Acta 297 (1973) 297–299. [DOI] [PMID: 4574550]
2.  Racker, E. The mechanism of action of glyoxalase. J. Biol. Chem. 190 (1951) 685–696. [PMID: 14841219]
[EC created 1961]

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