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Your query returned 1 entry. Printable version
EC | 4.6.1.18 | ||||||||||
Accepted name: | pancreatic ribonuclease | ||||||||||
Reaction: | (1) an [RNA] containing cytidine + H2O = an [RNA]-3′-cytidine-3′-phosphate + a 5′-hydroxy-ribonucleotide-3′-[RNA] (overall reaction) (1a) an [RNA] containing cytidine = an [RNA]-3′-cytidine-2′,3′-cyclophosphate + a 5′-hydroxy-ribonucleotide-3′-[RNA] (1b) an [RNA]-3′-cytidine-2′,3′-cyclophosphate + H2O = an [RNA]-3′-cytidine-3′-phosphate (2) an [RNA] containing uridine + H2O = an [RNA]-3′-uridine-3′-phosphate + a 5′-hydroxy-ribonucleotide-3′-[RNA] (2a) an [RNA] containing uridine = an [RNA]-3′-uridine-2′,3′-cyclophosphate + a 5′-hydroxy-ribonucleotide-3′-[RNA] (2b) an [RNA]-3′-uridine-2′,3′-cyclophosphate + H2O = an [RNA]-3′-uridine-3′-phosphate |
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Other name(s): | RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3′-pyrimidino-oligonucleotidohydrolase | ||||||||||
Systematic name: | RNA lyase ([RNA]-3′-cytidine/uridine-3′-phosphate and 5′-hydroxy-ribonucleotide-3′-[RNA] producing) | ||||||||||
Comments: | Specifically cleaves at the 3′-side of pyrimidine (uracil or cytosine) phosphate bonds in RNA. The reaction takes place in two steps, with the 2′,3′-cyclic phosphodiester intermediates released from the enzyme at the completion of the first step. Hydrolysis of these cyclic compounds occurs at a much slower rate through a reversal of the first step, in which the -OH group of water substitutes for the 2′-OH group of the ribose used in the first step, and does not take place until essentially all the susceptible 3′,5′-phosphodiester bonds have been cyclised. The enzyme can act as an endo- or exo ribonuclease. | ||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9001-99-4 | ||||||||||
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