| EC |
4.99.1.11 |
| Accepted name: |
sirohydrochlorin nickelchelatase |
| Reaction: |
Ni-sirohydrochlorin + 2 H+ = sirohydrochlorin + Ni2+ |
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| Other name(s): |
cfbA (gene name) |
| Systematic name: |
Ni-sirohydrochlorin nickel-lyase (sirohydrochlorin-forming) |
| Comments: |
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase. It catalyses the insertion of the nickel ion into sirohydrochlorin. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Zheng, K., Ngo, P.D., Owens, V.L., Yang, X.P. and Mansoorabadi, S.O. The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea. Science 354 (2016) 339–342. [DOI] [PMID: 27846569] |
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| [EC 4.99.1.11 created 2017] |
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