| EC |
4.99.1.8 |
| Accepted name: |
heme ligase |
| Reaction: |
2 ferriprotoporphyrin IX = β-hematin |
| Other name(s): |
heme detoxification protein; HDP; hemozoin synthase |
| Systematic name: |
Fe3+:ferriprotoporphyrin IX ligase (β-hematin-forming) |
| Comments: |
This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin. These organisms lack the mammalian heme oxygenase for elimination of heme. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Jani, D., Nagarkatti, R., Beatty, W., Angel, R., Slebodnick, C., Andersen, J., Kumar, S. and Rathore, D. HDP-a novel heme detoxification protein from the malaria parasite. PLoS Pathog. 4 (2008) e1000053. [DOI] [PMID: 18437218] |
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| [EC 4.99.1.8 created 2009] |
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