ExplorEnz: EC 5.1.3.45

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5.1.3.45

Accepted name:

UDP-N-acetyl-α-D-glucosaminouronate 4-epimerase

Reaction:

UDP-N-acetyl-α-D-glucosaminouronate = UDP-N-acetyl-α-D-galactosaminouronate

Other name(s):

tviC (gene name); wbpP (gene name); UDP-N-acetylglucosaminuronic acid 4-epimerase

Systematic name:

UDP-N-acetyl-α-D-glucosaminouronate 4-epimerase

Comments:

The enzyme is found in bacteria and participates in the biosynthesis of assorted bacterial lipopolysaccharides and capsular polysaccharides. It contains a tightly-bound NAD(H) cofactor. The enzyme also catalyses the activity of EC 5.1.3.7, UDP-N-acetylglucosamine 4-epimerase, with lower efficiency.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Ishiyama, N., Creuzenet, C., Lam, J.S. and Berghuis, A.M. Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: substrate specificity in udp-hexose 4-epimerases. J. Biol. Chem. 279 (2004) 22635–22642. [DOI] [PMID: 15016816]
2.	Zhang, H., Zhou, Y., Bao, H. and Liu, H.W. Vi antigen biosynthesis in Salmonella typhi: characterization of UDP-N-acetylglucosamine C-6 dehydrogenase (TviB) and UDP-N-acetylglucosaminuronic acid C-4 epimerase (TviC). Biochemistry 45 (2006) 8163–8173. [DOI] [PMID: 16800641]
3.	Miller, W.L., Matewish, M.J., McNally, D.J., Ishiyama, N., Anderson, E.M., Brewer, D., Brisson, J.R., Berghuis, A.M. and Lam, J.S. Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO. J. Biol. Chem. 283 (2008) 3507–3518. [DOI] [PMID: 18065759]

[EC 5.1.3.45 created 2024]