ExplorEnz: EC 5.2.1.4

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5.2.1.4

Accepted name:

maleylpyruvate isomerase

Reaction:

3-maleylpyruvate = 3-fumarylpyruvate

Other name(s):

nagL (gene name); ncgl2918 (gene name); PA2437 (gene name)

Systematic name:

3-maleylpyruvate cis-trans-isomerase

Comments:

The enzyme participates in a gentisate degradation pathway. Characterized enzymes require a thiol cofactor, though enzymes from different organisms utilize different thiols (e.g. glutathione, mycothiol, and L-cysteine).

Links to other databases:

BRENDA, EXPASY, GENE, KEGG, MetaCyc, PDB, CAS registry number: 9023-77-2

References:

1.	Lack, L. Enzymic cis-trans isomerization of maleylpyruvic acid. J. Biol. Chem. 236 (1961) 2835–2840. [DOI] [PMID: 14461395]
2.	Zhou, N.Y., Fuenmayor, S.L. and Williams, P.A. nag genes of Ralstonia (formerly Pseudomonas) sp. strain U2 encoding enzymes for gentisate catabolism. J. Bacteriol. 183 (2001) 700–708. [DOI] [PMID: 11133965]
3.	Feng, J., Che, Y., Milse, J., Yin, Y.J., Liu, L., Ruckert, C., Shen, X.H., Qi, S.W., Kalinowski, J. and Liu, S.J. The gene ncgl2918 encodes a novel maleylpyruvate isomerase that needs mycothiol as cofactor and links mycothiol biosynthesis and gentisate assimilation in Corynebacterium glutamicum. J. Biol. Chem. 281 (2006) 10778–10785. [DOI] [PMID: 16481315]
4.	Hong, H., Seo, H. and Kim, K.J. Structure and biochemical studies of a pseudomonad maleylpyruvate isomerase from Pseudomonas aeruginosa PAO1. Biochem. Biophys. Res. Commun. 514 (2019) 991–997. [DOI] [PMID: 31092332]

[EC 5.2.1.4 created 1965]