The Enzyme Database

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Accepted name: glucose-6-phosphate isomerase
Reaction: α-D-glucose 6-phosphate = β-D-fructofuranose 6-phosphate
For diagram of the calvin cycle, click here, for diagram of the calvin cycle, click here, for diagram of the pentose phosphate pathway (later stages), click here and for diagram of glycolysis, click here
Other name(s): phosphohexose isomerase; phosphohexomutase; oxoisomerase; hexosephosphate isomerase; phosphosaccharomutase; phosphoglucoisomerase; phosphohexoisomerase; phosphoglucose isomerase; glucose phosphate isomerase; hexose phosphate isomerase; D-glucose-6-phosphate ketol-isomerase
Systematic name: α-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)
Comments: The enzyme from yeast catalyses the reversible conversion specifically between the α-D-glucose 6-phosphate and β-D-fructofuranose 6-phosphate. The enzyme also catalyses the anomerization of both D-hexose 6-phosphates [7].
Links to other databases: BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9001-41-6
1.  Ramasarma, T. and Giri, K.V. Phosphoglucose isomerase of green gram (Phaseolus radiatus). Arch. Biochem. Biophys. 62 (1956) 91–96. [DOI] [PMID: 13314642]
2.  Tsuboi, K.K., Estrada, J. and Hudson, P.B. Enzymes of the human erythrocytes. IV. Phosphoglucose isomerase, purification and properties. J. Biol. Chem. 231 (1958) 19–29. [PMID: 13538944]
3.  Noltmann, E. and Bruns, F.H. Reindarstellung und Eigenschaften von Phosphoglucose-isomerase aus Hefe. Biochem. Z. 331 (1959) 436–445.
4.  Baich, A., Wolfe, R.G. and Reithel, F.J. The enzymes of mammary gland. I. Isolation of phosphoglucose isomerase. J. Biol. Chem. 235 (1960) 3130–3133. [PMID: 13685918]
5.  Noltmann, E.A. Isolation of crystalline phosphoglucose isomerase from rabbit muscle. J. Biol. Chem. 239 (1964) 1545–1550. [PMID: 14189891]
6.  Nakagawa, Y. and Noltmann, E.A. Isolation of crystalline phosphoglucose isomerase from brewers' yeast. J. Biol. Chem. 240 (1965) 1877–1881. [PMID: 14299604]
7.  Willem, R., Biesemans, M., Hallenga, K., Lippens, G., Malaisse-Lagae, F. and Malaisse, W.J. Dual anomeric specificity and dual anomerase activity of phosphoglucoisomerase quantified by two-dimensional phase-sensitive 13C EXSY NMR. J. Biol. Chem. 267 (1992) 210–217. [PMID: 1730590]
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