The Enzyme Database

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Accepted name: steroid Δ-isomerase
Reaction: a 3-oxo-Δ5-steroid = a 3-oxo-Δ4-steroid
For diagram of cholesterol catabolism (rings A, B and C), click here
Other name(s): hydroxysteroid isomerase; steroid isomerase; Δ5-ketosteroid isomerase; Δ5(or Δ4)-3-keto steroid isomerase; Δ5-steroid isomerase; 3-oxosteroid isomerase; Δ5-3-keto steroid isomerase; Δ5-3-oxosteroid isomerase
Systematic name: 3-oxosteroid Δ54-isomerase
Comments: This activity is catalysed by several distinct enzymes (cf. EC, cholesterol oxidase and EC, 3-hydroxy-5-steroid dehydrogenase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9031-36-1
1.  Ewald, W., Werbein, H. and Chaikoff, I.L. Evidence for the presence of 17-hydroxypregnenedione isomerase in beef adrenal cortex. Biochim. Biophys. Acta 111 (1965) 306–312. [DOI] [PMID: 5867327]
2.  Kawahara, F.S. and Talalay, P. Crystalline Δ5-3-ketosteroid isomerase. J. Biol. Chem. 235 (1960) PC1–PC2. [PMID: 14404954]
3.  Talalay, P. and Wang, V.S. Enzymic isomerization of Δ5-3-ketosteroids. Biochim. Biophys. Acta 18 (1955) 300–301. [PMID: 13276386]
4.  MacLachlan, J., Wotherspoon, A.T., Ansell, R.O. and Brooks, C.J. Cholesterol oxidase: sources, physical properties and analytical applications. J. Steroid Biochem. Mol. Biol. 72 (2000) 169–195. [DOI] [PMID: 10822008]
[EC created 1961]

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