The Enzyme Database

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Accepted name: neopinone isomerase
Reaction: neopinone = codeinone
Glossary: neopinone = 3-methoxy-17-methyl-8,14-didehydro-4,5α-epoxymorphinan-6-one
codeinone = 3-methoxy-17-methyl-7,8-didehydro-4,5α-epoxymorphinan-6-one
Other name(s): NISO (gene name)
Systematic name: neopinone Δ87-isomerase
Comments: The enzyme, characterized from the opium poppy (Papaver somniferum), participates in the biosynthesis of morphine. It also catalyses the isomerization of neomorphinone and morphinone.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Dastmalchi, M., Chen, X., Hagel, J.M., Chang, L., Chen, R., Ramasamy, S., Yeaman, S. and Facchini, P.J. Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy. Nat. Chem. Biol. 15 (2019) 384–390. [DOI] [PMID: 30886433]
[EC created 2022]

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