ExplorEnz: EC 5.3.3.24

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5.3.3.24

Accepted name:

neopinone isomerase

Reaction:

neopinone = codeinone

Glossary:

neopinone = 3-methoxy-17-methyl-8,14-didehydro-4,5α-epoxymorphinan-6-one
codeinone = 3-methoxy-17-methyl-7,8-didehydro-4,5α-epoxymorphinan-6-one

Other name(s):

NISO (gene name)

Systematic name:

neopinone Δ⁸-Δ⁷-isomerase

Comments:

The enzyme, characterized from the opium poppy (Papaver somniferum), participates in the biosynthesis of morphine. It also catalyses the isomerization of neomorphinone and morphinone.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Dastmalchi, M., Chen, X., Hagel, J.M., Chang, L., Chen, R., Ramasamy, S., Yeaman, S. and Facchini, P.J. Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy. Nat. Chem. Biol. 15 (2019) 384–390. [DOI] [PMID: 30886433]

[EC 5.3.3.24 created 2022]