The Enzyme Database

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Accepted name: β-phosphoglucomutase
Reaction: β-D-glucose 1-phosphate = β-D-glucose 6-phosphate
For diagram of reaction, click here
Other name(s): β-pgm (gene name)
Systematic name: β-D-glucose 1,6-phosphomutase
Comments: The enzyme requires Mg2+ and phosphorylation of an aspartate residue at the active site. The enzyme is able to autophosphorylate itself with its substrate β-D-glucose 1-phosphate. Although this is a slow reaction, only a single turnover is required for activation. Once the phosphorylated enzyme is formed, it generates the reaction intermediate β-D-glucose 1,6-bisphosphate, which can be used to phosphorylate the enzyme in subsequent cycles [4]. cf. EC, phosphoglucomutase (α-D-glucose-1,6-bisphosphate-dependent).
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 68651-99-0
1.  Ben-Zvi, R. and Schramm, M. A phosphoglucomutase specific for β-glucose 1-phosphate. J. Biol. Chem. 236 (1961) 2186–2189.
2.  Ray, W.J., Jr. and Peck, E.J., Jr. Phosphomutases. In: Boyer, P.D. (Ed.), The Enzymes, 3rd edn, vol. 6, 1972, pp. 407–477.
3.  Lahiri, S.D., Zhang, G., Dunaway-Mariano, D. and Allen, K.N. The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction. Science 299 (2003) 2067–2071. [DOI] [PMID: 12637673]
4.  Dai, J., Wang, L., Allen, K.N., Radstrom, P. and Dunaway-Mariano, D. Conformational cycling in β-phosphoglucomutase catalysis: reorientation of the β-D-glucose 1,6-(Bis)phosphate intermediate. Biochemistry 45 (2006) 7818–7824. [DOI] [PMID: 16784233]
[EC created 1984]

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