The Enzyme Database

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Accepted name: tRNA pseudouridine38/39 synthase
Reaction: tRNA uridine38/39 = tRNA pseudouridine38/39
Other name(s): Deg1; Pus3p; pseudouridine synthase 3
Systematic name: tRNA-uridine38/39 uracil mutase
Comments: The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39, and shows no activity with uridine40 (cf. EC, tRNA pseudouridine38-40 synthase) [1]. In vitro the enzyme from mouse is active on uridine39 and very slightly on uridine38 (human tRNALeu) [2].
Links to other databases: BRENDA, EXPASY, Gene, KEGG, MetaCyc
1.  Lecointe, F., Simos, G., Sauer, A., Hurt, E.C., Motorin, Y. and Grosjean, H. Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of Ψ38 and Ψ39 in tRNA anticodon loop. J. Biol. Chem. 273 (1998) 1316–1323. [DOI] [PMID: 9430663]
2.  Chen, J. and Patton, J.R. Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA. Biochemistry 39 (2000) 12723–12730. [DOI] [PMID: 11027153]
[EC created 2011]

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