EC |
5.4.99.45 |
Accepted name: |
tRNA pseudouridine38/39 synthase |
Reaction: |
tRNA uridine38/39 = tRNA pseudouridine38/39 |
Other name(s): |
Deg1; Pus3p; pseudouridine synthase 3 |
Systematic name: |
tRNA-uridine38/39 uracil mutase |
Comments: |
The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39, and shows no activity with uridine40 (cf. EC 5.4.99.12, tRNA pseudouridine38-40 synthase) [1]. In vitro the enzyme from mouse is active on uridine39 and very slightly on uridine38 (human tRNALeu) [2]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Lecointe, F., Simos, G., Sauer, A., Hurt, E.C., Motorin, Y. and Grosjean, H. Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of Ψ38 and Ψ39 in tRNA anticodon loop. J. Biol. Chem. 273 (1998) 1316–1323. [DOI] [PMID: 9430663] |
2. |
Chen, J. and Patton, J.R. Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA. Biochemistry 39 (2000) 12723–12730. [DOI] [PMID: 11027153] |
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[EC 5.4.99.45 created 2011] |
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