The Enzyme Database

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Accepted name: precorrin-8X methylmutase
Reaction: precorrin-8X = hydrogenobyrinate
For diagram of corrin biosynthesis (part 4), click here
Other name(s): precorrin isomerase; hydrogenobyrinic acid-binding protein; cobH (gene name)
Systematic name: precorrin-8X 11,12-methylmutase
Comments: The enzyme, which participates in the aerobic (late cobalt insertion) adenosylcobalamin biosynthesis pathway, catalyses the conversion of precorrin-8X to hydrogenobyrinate by methyl rearrangement. The equivalent enzyme in the anaerobic pathway is EC, cobalt-precorrin-8 methylmutase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 138238-71-8
1.  Thibaut, D., Couder, M., Famechon, A., Debussche, L., Cameron, B., Crouzet, J., Blanche, F. The final step in the biosynthesis of hydrogenobyrinic acid is catalyzed by the cobH gene product with precorrin-8X as the substrate. J. Bacteriol. 174 (1992) 1043–1049. [DOI] [PMID: 1732194]
2.  Crouzet, J., Cameron, B., Cauchois, L., Rigault, S., Rouyez, M.C., Blanche, F. , Thibaut D., Debussche, L. Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid. J. Bacteriol. 172 (1990) 5980–5990. [DOI] [PMID: 2211521]
3.  Shipman, L.W., Li, D., Roessner, C.A., Scott, A.I. and Sacchettini, J.C. Crystal structure of precorrin-8x methyl mutase. Structure 9 (2001) 587–596. [DOI] [PMID: 11470433]
[EC created 1999 as EC, transferred 2014 to EC]

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