| EC |
5.5.1.11 |
| Accepted name: |
dichloromuconate cycloisomerase |
| Reaction: |
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate |
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For diagram of reaction, click here |
| Other name(s): |
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing) |
| Systematic name: |
2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening) |
| Comments: |
Requires Mn2+. The product of cycloisomerization of dichloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylene-3-chlorobut-2-en-4-olide. Also acts, in the reverse direction, on cis,cis-muconate and its monochloro-derivatives, but with lower affinity. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.7 (chloromuconate cycloisomerase). |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 126904-95-8 |
| References: |
| 1. |
Kuhm, A.E., Schlömann, M., Knackmuss, H.-J. and Pieper, D.H. Purification and characterization of dichloromuconate cycloisomerase from Alcaligenes eutrophus JMP 134. Biochem. J. 266 (1990) 877–883. [PMID: 2327971] |
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| [EC 5.5.1.11 created 1992] |
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