| EC |
5.5.1.16 |
| Accepted name: |
halimadienyl-diphosphate synthase |
| Reaction: |
geranylgeranyl diphosphate = tuberculosinyl diphosphate |
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For diagram of diterpenoid biosynthesis, click here |
| Glossary: |
tuberculosinyl diphosphate = halima-5,13-dien-15-yl diphosphate |
| Other name(s): |
Rv3377c; halimadienyl diphosphate synthase; tuberculosinol diphosphate synthase; halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing); halima-5,13-dien-15-yl-diphosphate lyase (decyclizing) |
| Systematic name: |
halima-5,13-dien-15-yl-diphosphate lyase (ring-opening) |
| Comments: |
Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Nakano, C., Okamura, T., Sato, T., Dairi, T. and Hoshino, T. Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton. Chem. Commun. (Camb.) (2005) 1016–1018. [DOI] [PMID: 15719101] |
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| [EC 5.5.1.16 created 2008, modified 2012] |
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