EC |
5.6.1.5 |
Accepted name: |
proteasome ATPase |
Reaction: |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide |
Systematic name: |
ATP phosphohydrolase (polypeptide-degrading) |
Comments: |
Belongs to the AAA-type superfamily and, like EC 5.6.1.4 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
References: |
1. |
Rivett, A.J., Mason, G.G., Murray, R.Z. and Reidlinger, J. Regulation of proteasome structure and function. Mol. Biol. Rep. 24 (1997) 99–102. [PMID: 9228289] |
2. |
Mason, G.G., Murray, R.Z., Pappin, D. and Rivett, A.J. Phosphorylation of ATPase subunits of the 26S proteasome. FEBS Lett. 430 (1998) 269–274. [DOI] [PMID: 9688553] |
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[EC 5.6.1.5 created 2000 as 3.6.4.8, transferred 2018 to EC 5.6.1.5] |
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