EC |
5.6.2.2 |
Accepted name: |
DNA topoisomerase (ATP-hydrolysing) |
Reaction: |
ATP-dependent breakage, passage and rejoining of double-stranded DNA |
Other name(s): |
type II DNA topoisomerase; DNA-gyrase; deoxyribonucleate topoisomerase; deoxyribonucleic topoisomerase; topoisomerase; DNA topoisomerase II |
Systematic name: |
DNA topoisomerase (ATP-hydrolysing) |
Comments: |
The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.6.2.1 DNA topoisomerase). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 142805-56-9 |
References: |
1. |
Gellert, M. DNA topoisomerases. Annu. Rev. Biochem. 50 (1981) 879–910. [DOI] [PMID: 6267993] |
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[EC 5.6.2.2 created 1984 as 5.99.1.3, transferred 2019 to EC 5.6.2.2] |
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