ExplorEnz: EC 6.1.1.1

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6.1.1.1

Accepted name:

tyrosine—tRNA ligase

Reaction:

ATP + L-tyrosine + tRNA^Tyr = AMP + diphosphate + L-tyrosyl-tRNA^Tyr

Systematic name:

L-tyrosine:tRNA^Tyr ligase (AMP-forming)

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9023-45-4

References:

1.	Allen, E.H., Glassman, E. and Schweet, R.S. Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes. J. Biol. Chem. 235 (1960) 1061–1067. [PMID: 13792726]
2.	Cowles, J.R. and Key, J.L. Demonstration of two tyrosyl-tRNA synthetases of pea roots. Biochim. Biophys. Acta 281 (1972) 33–44. [DOI] [PMID: 4563531]
3.	Holley, R.W., Brunngraber, E.F., Saad, F. and Williams, H.H. Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of potassium ions on the activity of the tyrosine enzyme. J. Biol. Chem. 236 (1961) 197–199. [PMID: 13715350]
4.	Schweet, R.S. and Allen, E.H. Purification and properties of tyrosine-activating enzyme of hog pancreas. J. Biol. Chem. 233 (1958) 1104–1108. [PMID: 13598741]
5.	Brick, P., Bhat, T.N. and Blow, D.M. Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate. J. Mol. Biol. 208 (1989) 83–98. [DOI] [PMID: 2504923]

[EC 6.1.1.1 created 1961, modified 2002]