| EC |
6.1.1.10 |
| Accepted name: |
methionine—tRNA ligase |
| Reaction: |
ATP + L-methionine + tRNAMet = AMP + diphosphate + L-methionyl-tRNAMet |
| Other name(s): |
methionyl-tRNA synthetase; methionyl-transfer ribonucleic acid synthetase; methionyl-transfer ribonucleate synthetase; methionyl-transfer RNA synthetase; methionine translase; MetRS |
| Systematic name: |
L-methionine:tRNAMet ligase (AMP-forming) |
| Comments: |
In those organisms producing N-formylmethionyl-tRNAfMet for translation initiation, this enzyme also recognizes the initiator tRNAfMet and catalyses the formation of L-methionyl-tRNAfMet, the substrate for EC 2.1.2.9, methionyl-tRNA formyltransferase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9033-22-1 |
| References: |
| 1. |
Bergmann, F.H., Berg, P. and Dieckmann, M. The enzymic synthesis of amino acyl derivatives of ribonucleic acid. II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli. J. Biol. Chem. 236 (1961) 1735–1740. |
| 2. |
Lee, C.P., Dyson, M.R., Mandal, N., Varshney, U., Bahramian, B. and RajBhandary, U.L. Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase. Proc. Natl. Acad. Sci. USA 89 (1992) 9262–9266. [DOI] [PMID: 1409632] |
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| [EC 6.1.1.10 created 1961, modified 2002] |
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