ExplorEnz: EC 6.1.1.13

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6.1.1.13

Accepted name:

D-alanine—poly(phosphoribitol) ligase

Reaction:

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)

Other name(s):

D-alanyl-poly(phosphoribitol) synthetase; D-alanine: membrane acceptor ligase; D-alanine-D-alanyl carrier protein ligase; D-alanine-membrane acceptor ligase; D-alanine-activating enzyme

Systematic name:

D-alanine:poly(phosphoribitol) ligase (AMP-forming)

Comments:

A thioester bond is formed transiently between D-alanine and the sulfhydryl group of the 4′-phosphopantetheine cofactor of D-alanyl carrier protein during the activation of the alanine. Involved in the synthesis of teichoic acids.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9023-65-8

References:

1.	Baddiley, J. and Neuhaus, F.C. The enzymic activation of D-alanine. Biochem. J. 75 (1960) 579. [PMID: 13795638]
2.	Reusch, V.M. and Neuhaus, F.C. D-Alanine:membrane acceptor ligase from Lactobacillus casei. J. Biol. Chem. 246 (1971) 6136–6143. [PMID: 4399593]
3.	Perego, M., Glaser, P., Minutello, A., Strauch, M.A., Leopold, K. and Fischer, W. Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation. J. Biol. Chem. 270 (1995) 15598–15606. [DOI] [PMID: 7797557]
4.	Heaton, M.P. and Neuhaus, F.C. Role of D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid. J. Bacteriol. 176 (1994) 681–690. [DOI] [PMID: 8300523]
5.	Debabov, D.V., Heaton, M.P., Zhang, Q., Stewart, K.D., Lambalot, R.H. and Neuhaus, F.C. The D-alanyl carrier protein in Lactobacillus casei: cloning, sequencing and expression of dltC. J. Bacteriol. 178 (1996) 3869–3876. [DOI] [PMID: 8682792]

[EC 6.1.1.13 created 1965, modified 2001]