ExplorEnz: EC 6.1.3.1

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6.1.3.1

Accepted name:

olefin β-lactone synthetase

Reaction:

ATP + a (2R,3S)-2-alkyl-3-hydroxyalkanoate = AMP + diphosphate + a cis-3-alkyl-4-alkyloxetan-2-one

Other name(s):

oleC (gene name)

Systematic name:

(2R,3S)-2-alkyl-3-hydroxyalkanoate ligase (β-lactone,AMP-forming)

Comments:

The enzyme, found in certain bacterial species, participates in a pathway for the production of olefins. It forms a β-lactone. The alkyl group at C² of the substrate ends up as the 3-alkyl group of the product.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Sukovich, D.J., Seffernick, J.L., Richman, J.E., Hunt, K.A., Gralnick, J.A. and Wackett, L.P. Structure, function, and insights into the biosynthesis of a head-to-head hydrocarbon in Shewanella oneidensis strain MR-1. Appl. Environ. Microbiol. 76 (2010) 3842–3849. [DOI] [PMID: 20418444]
2.	Frias, J.A., Goblirsch, B.R., Wackett, L.P. and Wilmot, C.M. Cloning, purification, crystallization and preliminary X-ray diffraction of the OleC protein from Stenotrophomonas maltophilia involved in head-to-head hydrocarbon biosynthesis. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (2010) 1108–1110. [DOI] [PMID: 20823539]
3.	Kancharla, P., Bonnett, S.A. and Reynolds, K.A. Stenotrophomonas maltophilia OleC-catalyzed ATP-dependent formation of long-chain Z-olefins from 2-alkyl-3-hydroxyalkanoic acids. ChemBioChem 17 (2016) 1426–1429. [DOI] [PMID: 27238740]
4.	Christenson, J.K., Richman, J.E., Jensen, M.R., Neufeld, J.Y., Wilmot, C.M. and Wackett, L.P. β-Lactone synthetase found in the olefin biosynthesis pathway. Biochemistry 56 (2017) 348–351. [DOI] [PMID: 28029240]

[EC 6.1.3.1 created 2017]