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Your query returned 1 entry. Printable version
EC | 6.2.1.39 | ||
Accepted name: | [butirosin acyl-carrier protein]—L-glutamate ligase | ||
Reaction: | (1) ATP + L-glutamate + BtrI acyl-carrier protein = ADP + phosphate + L-glutamyl-[BtrI acyl-carrier protein] (2) ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] = ADP + phosphate + 4-(γ-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] |
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Other name(s): | [BtrI acyl-carrier protein]—L-glutamate ligase; BtrJ | ||
Systematic name: | [BtrI acyl-carrier protein]:L-glutamate ligase (ADP-forming) | ||
Comments: | Catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. The enzyme adds one molecule of L-glutamate to a dedicated acyl-carrier protein, and following decarboxylation of the product by EC 4.1.1.95, L-glutamyl-[BtrI acyl-carrier protein] decarboxylase, adds a second L-glutamate molecule. Requires Mg2+ or Mn2+, and activity is enhanced in the presence of Mn2+. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
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