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Your query returned 1 entry. Printable version
EC | 6.2.1.57 | ||||
Accepted name: | long-chain fatty acid adenylase/transferase FadD23 | ||||
Reaction: | (1) ATP + stearate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a stearoyl-[(hydroxy)phthioceranic acid synthase] (overall reaction) (1a) ATP + stearate = diphosphate + (stearoyl)adenylate (1b) (stearoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a stearoyl-[(hydroxy)phthioceranic acid synthase] (2) ATP + palmitate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a palmitoyl-[(hydroxy)phthioceranic acid synthase] (overall reaction) (2a) ATP + palmitate = diphosphate + (palmitoyl)adenylate (2b) (palmitoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a palmitoyl-[(hydroxy)phthioceranic acid synthase] |
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Other name(s): | fadD23 (gene name); long-chain fatty acid adenylyltransferase FadD23 | ||||
Systematic name: | palmitate:holo-[(hydroxy)phthioceranic acid synthase] ligase | ||||
Comments: | This mycobacterial enzyme activates palmitate and stearate by adenylation, followed by their loading onto the polyketide synthase EC 2.3.1.287, phthioceranic/hydroxyphthioceranic acid synthase. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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