ExplorEnz: EC 6.2.1.78

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6.2.1.78

Accepted name:

(3R)-β-phenylalanine—CoA ligase

Reaction:

ATP + (3R)-β-phenylalanine + CoA = AMP + diphosphate + (3R)-β-phenylalanyl-CoA (overall reaction)
(1a) ATP + (3R)-β-phenylalanine = diphosphate + 5′-adenylyl L-phenylalanate
(1b) 5′-adenylyl L-phenylalanate + CoA = AMP + (3R)-β-phenylalanyl-CoA

Other name(s):

N7525_006484; β-phenylalanine coenzyme A ligase; TAAE16 (gene name)

Systematic name:

(3R)-β-phenylalanine:CoA ligase (AMP-forming)

Comments:

The enzyme, characterized from the fungus Penicillium chrysogenum, acts on (3R)-β-phenylalanine and has slight activity on some other amino acids including (3S)-β-phenylalanine. It also acts on medium-chain-length alkanoic acids as EC 6.2.1.2 (medium-chain acyl-CoA ligase). In taxol-producing trees the enzyme is involved in taxol biosynthesis.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Koetsier, M.J., Jekel, P.A., Wijma, H.J., Bovenberg, R.A. and Janssen, D.B. Aminoacyl-coenzyme A synthesis catalyzed by a CoA ligase from Penicillium chrysogenum. FEBS Lett. 585 (2011) 893–898. [DOI] [PMID: 21334330]

[EC 6.2.1.78 created 2025]