ExplorEnz: EC 6.3.1.10

Your query returned 1 entry. Printable version

6.3.1.10

Accepted name:

adenosylcobinamide-phosphate synthase

Reaction:

(1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate
(2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

For diagram of corrin biosynthesis (part 6), click here

Other name(s):

CbiB

Systematic name:

adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)

Comments:

One of the substrates for this reaction, (R)-1-aminopropan-2-yl phosphate, is produced by CobD (EC 4.1.1.81, threonine-phosphate decarboxylase).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 905988-16-1

References:

1.	Cheong, C.G., Bauer, C.B., Brushaber, K.R., Escalante-Semerena, J.C. and Rayment, I. Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica. Biochemistry 41 (2002) 4798–4808. [DOI] [PMID: 11939774]
2.	Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. The biosynthesis of adenosylcobalamin (vitamin B₁₂). Nat. Prod. Rep. 19 (2002) 390–412. [PMID: 12195810]

[EC 6.3.1.10 created 2004]