ExplorEnz: EC 6.3.2.1

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6.3.2.1

Accepted name:

pantoate—β-alanine ligase (AMP-forming)

Reaction:

ATP + (R)-pantoate + β-alanine = AMP + diphosphate + (R)-pantothenate

For diagram of coenzyme A biosynthesis (early stages), click here

Glossary:

(R)-pantoate = (2R)-2,4-dihydroxy-3,3-dimethylbutanoate
(R)-pantothenate = 3-[(2R)-2,4-dihydroxy-3,3-dimethylbutanamido]propanoate

Other name(s):

pantothenate synthetase; pantoate activating enzyme; pantoic-activating enzyme; D-pantoate:β-alanine ligase (AMP-forming); pantoate—β-alanine ligase (ambiguous)

Systematic name:

(R)-pantoate:β-alanine ligase (AMP-forming)

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9023-49-8

References:

1.	Ginoza, H.S. and Altenbern, R.A. The pantothenate-synthesizing enzyme cell-free extracts of Brucella abortus, strain 19. Arch. Biochem. Biophys. 56 (1955) 537–541. [DOI] [PMID: 14377603]
2.	Maas, W.K. Pantothenate studies. III. Description of the extracted pantothenate-synthesizing enzyme of Escherichia coli. J. Biol. Chem. 198 (1952) 23–32. [PMID: 12999714]
3.	Maas, W.K. Mechanism of the enzymatic synthesis of pantothenate from β-alanine and pantoate. Fed. Proc. 15 (1956) 305–306.

[EC 6.3.2.1 created 1961, modified 2014]