| EC |
6.3.2.2 |
| Accepted name: |
glutamate—cysteine ligase |
| Reaction: |
ATP + L-glutamate + L-cysteine = ADP + phosphate + γ-L-glutamyl-L-cysteine |
|
For diagram of glutathione biosynthesis, click here |
| Other name(s): |
γ-glutamylcysteine synthetase; γ-glutamyl-L-cysteine synthetase; γ-glutamylcysteinyl synthetase |
| Systematic name: |
L-glutamate:L-cysteine γ-ligase (ADP-forming) |
| Comments: |
Can use L-aminohexanoate in place of glutamate. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9023-64-7 |
| References: |
| 1. |
MacKinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B. and Fothergill, J.E. Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence. Eur. J. Biochem. 169 (1987) 547–553. [DOI] [PMID: 3500856] |
| 2. |
Snoke, J.E., Yanari, S. and Bloch, K. Synthesis of glutathione from γ-glutamylcysteine. J. Biol. Chem. 201 (1953) 573–586. [PMID: 13061393] |
| 3. |
Mandeles, S. and Bloch, K. Enzymatic synthesis of γ-glutamylcysteine. J. Biol. Chem. 214 (1955) 639–646. [PMID: 14381401] |
|
| [EC 6.3.2.2 created 1961] |
| |
|
| |
|
Printable version