| EC |
6.3.2.33 |
| Accepted name: |
tetrahydrosarcinapterin synthase |
| Reaction: |
ATP + tetrahydromethanopterin + L-glutamate = ADP + phosphate + 5,6,7,8-tetrahydrosarcinapterin |
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For diagram of methanopterin biosynthesis (part 4), click here |
| Other name(s): |
H4MPT:α-L-glutamate ligase; MJ0620; MptN protein |
| Systematic name: |
tetrahydromethanopterin:α-L-glutamate ligase (ADP-forming) |
| Comments: |
This enzyme catalyses the biosynthesis of 5,6,7,8-tetrahydrosarcinapterin, a modified form of tetrahydromethanopterin found in the Methanosarcinales. It does not require K+, and does not discriminate between ATP and GTP [1]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Li, H., Xu, H., Graham, D.E. and White, R.H. Glutathione synthetase homologs encode α-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses. Proc. Natl. Acad. Sci. USA 100 (2003) 9785–9790. [DOI] [PMID: 12909715] |
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| [EC 6.3.2.33 created 2010] |
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