The Enzyme Database

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Accepted name: L-arginine-specific L-amino acid ligase
Reaction: ATP + L-arginine + an L-amino acid = ADP + phosphate + an L-arginyl-L-amino acid
Other name(s): RizA; L-amino acid ligase RizA
Systematic name: L-arginine:L-amino acid ligase (ADP-forming)
Comments: The enzyme, characterized from the bacterium Bacillus subtilis, requires Mn2+ for activity. It shows strict substrate specificity toward L-arginine as the first (N-terminal) amino acid of the product. The second amino acid could be any standard protein-building amino acid except for L-proline.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Kino, K., Kotanaka, Y., Arai, T. and Yagasaki, M. A novel L-amino acid ligase from Bacillus subtilis NBRC3134, a microorganism producing peptide-antibiotic rhizocticin. Biosci. Biotechnol. Biochem. 73 (2009) 901–907. [DOI] [PMID: 19352016]
[EC created 2015]

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