The Enzyme Database

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Accepted name: phosphopantothenate—cysteine ligase (CTP)
Reaction: CTP + (R)-4′-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4′-phosphopantothenoyl]-L-cysteine
For diagram of coenzyme A biosynthesis (late stages), click here
Other name(s): phosphopantothenoylcysteine synthetase (ambiguous); phosphopantothenate—cysteine ligase (ambiguous)
Systematic name: (R)-4′-phosphopantothenate:L-cysteine ligase
Comments: A key enzyme in the production of coenzyme A. The bacterial enzyme requires CTP, in contrast to the eukaryotic enzyme, EC, which requires ATP. Cysteine can be replaced by some of its derivatives.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9023-50-1
1.  Brown, G.M. The metabolism of pantothenic acid. J. Biol. Chem. 234 (1959) 370–378. [PMID: 13630913]
2.  Strauss, E., Kinsland, C., Ge, Y., McLafferty, F.W. and Begley, T.P. Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified Coenzyme A biosynthetic enzymes in bacteria. J. Biol. Chem. 276 (2001) 13513–13516. [DOI] [PMID: 11278255]
3.  Kupke, T. Molecular characterization of the 4′-phosphopantothenoylcysteine synthetase domain of bacterial Dfp flavoproteins. J. Biol. Chem. 277 (2002) 36137–36145. [DOI] [PMID: 12140293]
[EC created 1961, modified 2003, modified 2017]

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