| EC |
6.3.3.1 |
| Accepted name: |
phosphoribosylformylglycinamidine cyclo-ligase |
| Reaction: |
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole |
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For diagram of the early stages of purine biosynthesis, click here |
| Other name(s): |
phosphoribosylaminoimidazole synthetase; AIR synthetase; 5′-aminoimidazole ribonucleotide synthetase; 2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) |
| Systematic name: |
2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9023-53-4 |
| References: |
| 1. |
Levenberg, B. and Buchanan, J.M. Properties of the purines. XII. Structure, enzymatic synthesis, and metabolism of 5-aminoimidazole ribotide. J. Biol. Chem. 224 (1957) 1005–1018. [PMID: 13405929] |
| 2. |
Levenberg, B. and Buchanan, J.M. Biosynthesis of the purines. XIII. Structure, enzymatic synthesis, and metabolism of (α-N-formyl)-glycinamidine ribotide. J. Biol. Chem. 224 (1957) 1018–1027. [PMID: 13405930] |
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| [EC 6.3.3.1 created 1961, modified 2000] |
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